Analgecine (AGC®) is a key product of Vanway which is solely produced in Vanworld Pharmaceutical Co Ltd. Rugao in Jiangsu. It is a natural bio-product obtained from rabbit skin extract through vaccinia virus inoculation inflammation as an antigen immune reaction.
Its non-protein substance is effective in regulating the disorder of nervous system, internal secretion and immune system. Drug reports showed that Analgecine contains at least 13 kinds of amino acids and 5 kinds of nucleotides. As of its exceptional light molecule weight under 5000 daltons, it can easily pass through the brain blood vessels.
Analgecine is recognized as one of the front line drugs, not only because of its high efficacy, but also noted for its safety in use with low side effect.
- Cure neck-shoulder-wrist syndrome
- Relieve pain, cold sensation and numbness of patients suffering from low back pain
It was found that nurturing PC12h cells obtained from pheochromocytoma in culture solution caused slow growth of neurite (as shown in figure 1 below). After adding Analgecine into the culture solution, the neurite grew rapidly, and the numbers of microvilli and synaptic vesicles were clearly increased (figure 2).
Figure 1: Conventional growth media
Figure 2: Conventional growth media with Analgecine
Analgecine is effective in promoting the multiplication speed of Schwann cell of S stage which consequently Schwann cells increased (Figure 4). Thus, it was concluded that Analgecine is effective in repairing damaged nerves.
Figure 3: Conventional culture solution
Figure 4: Conventional culture solution with Analgecine
In vitro test of the neurons taken from the CA1 area of rat brain hippocampus under regular oxygen partial pressure (90 mmHg) showed the membrane potential of the nerve cell is -70 MV; 10 minutes after adding Analgecine to the cell culture solution, the membrane potential did not show abnormal change.
Lowering the oxygen partial pressure to 60 mmHg (creating oxygen deficient condition) caused the rise of the membrane potential; adding Analgecine inhibited the rise of the membrane potential, and the inhibition degree was related to Analgecine concentration.
The test results indicated that Analgecine can inhibit the rise of the membrane potential of neurons under oxygen deficient condition, thereby protecting neurons that are under oxygen deficient condition.
Electrophysiological study on rat with diabetes caused by injection of streptozocin showed that the conduction velocity of sciatic nerve of the diabetes-inflicted rat became slow. After Aalgecine was administered, the conduction velocity was recovered clearly. And the recovery extent was related to Analgecine concentration.
Analgecine has analgesic function for both central and peripheral nerves. Its effect for chronic pain is not antagonized by naloxone. Nor does Analgecine affect the synthesis of prostaglandin. Therefore, Analgecine is different from convention analgesic drugs and
Analgesic for central nerve: activating descending pain inhibitory system
Analgecine acts on 5- hydroxytryptamine neurons to activate descending pain inhibitory system, showing analgesic function on central nerve system.
The descending pain inhibitory system is an important pain regulating unit and descends from hypothalamus, medulla to posterior horn of spinal cord to hyperpolarize the neurons of dorsal horn, inhibiting pain pulses from being transmitted to central nerves.
Analgesic for peripheral nerves: inhibiting the synthesis of bradykinin
Analgecine acts on the initial stage of plasma kininase-kinin chain reactions, inhibiting the generation of bradykinin, further alleviating periphery pain and obviating edema. Bradykinin is a small peptide having strong pain-causing effect and vascular dilating function.
Improving nerve symptoms, such as cold feel, numbness
In vivo studies and in vitro studies showed that Analgecine was capable of changing abnormal discharge of hypothalamus neurons, and it is commonly known that this abnormal discharge causes neuralgia and paresthesia. More than this, Analgecine was also proved capable in of regulating the activities of centre vegetative nerve and improving the dysfunction of vegetative nerve.
The above figures show the regulating effect of Analgeans on hypothalamus neurons.
Animal tests have shown that Analgecine was capable of fighting type I hypersensitivity and could inhibit pneogaster hypersecretion caused by the excitement of parasympathetic nerve. Analgecine could also suppress the density up-regulation of nasal mucosa M receptor. Clinical studies showed that pollen allergic patients could inhibit pollen antigen reaction in Prick test and could alleviate erythema caused by substance P skin administration.
Analgecine can restore the function of immune system that is either lowered or abnormally activated by regulating the functions of T cells and macrophages. One example is that Analgecine can improve NZK rat thymus reticulate structure disorder (hereditary autoimmune disease).